New York has long served as the heart of the media and advertising industries. Los Angeles, by contrast, pumps out a steady flow of popular culture and has its own agency scene to match. This global headquarters for the entertainment and production industries—with a dash of tech innovation—creates a wealth of opportunities for trend-smart ad shops that aren’t afraid to draw talent and collaborators from outside the “traditional” marketing world. As clients cut budgets and the storied broadcast TV model evolves, these organizations are increasingly comfortable moving beyond the familiar. Thankfully, their hometown has a wealth of alternatives to offer.