Campbell spent five years in Maryland in various roles in television and radio including her time at the NBC affiliate.
She is filing the position left open by reporter-anchor David MacAnally, who retired from the Indy station this summer.
“Karen is a real solid reporter and she is great on the [anchor] desk too. That’s really important to us. For us, it’s all about versatility,” said WTHR news director Jeff Rosetti.
Campbell will serve as a reporter and a fill-in anchor on the noon newscast as well on weekends. She begins Aug. 3.